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Category:Indian comedy films Category:Indian films Category:1990s Hindi-language films Category:Films directed by Mohan Trikha Category:Films scored by Bappi LahiriLiraglutide attenuates insulin resistance via regulating PI3K-AKT signaling pathway in hepatocytes. Glucagon-like peptide-1 (GLP-1) is a pancreatic polypeptide hormone with potent insulinotropic action. However, GLP-1 is rapidly degraded by dipeptidyl peptidase-4 (DPP-4). To characterize the effects of long-acting GLP-1 analog liraglutide on insulin signaling in hepatocytes and further to investigate the molecular mechanisms. Human hepatocyte cell line LO2 was treated with high glucose (HG), liraglutide or/and Wortmannin (an inhibitor of PI3K) to detect the level of p-AKT (Ser473) and AKT, the protein expression of DPP-4 and GLP-1 receptor (GLP-1R). The cellular uptake of 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG) and lipid accumulation was detected by flow cytometry. High glucose treatment significantly down-regulated the p-AKT, AKT, DPP-4 and GLP-1R in LO2 cells. Liraglutide treatment significantly up-regulated the p-AKT, AKT, DPP-4 and GLP-1R, accompanied by the increase of GLP-1R and GLP-1R protein level. Liraglutide treatment inhibited the high glucose-induced 2-NBDG uptake and lipid accumulation. Liraglutide down-regulated the protein level of phosphatase and tensin homolog (PTEN). Furthermore, the PI3K inhibitor (Wortmannin) significantly down-regulated p-AKT, p-GSK3β (Ser9) and DPP-4, while liraglutide didn't affect AKT, GSK3β, p-GSK3β (Ser9) and DPP-4 expression. These results suggest that liraglutide improved insulin resistance



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